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Taking the above discussion into consideration, with emphasis on long-term track record of safety [104, 135, 141] and activity beyond symptom control (i.e., suppression of clonal myeloproliferation) [113, 114, 142], in patients who are either intolerant to or show suboptimal response to HU, we prefer the use of peg-IFN for patients younger than age 65 years and busulfan in the older age group, although there is no controlled evidence to support or refute such a strategy

while in the UK over 400,000 patients paid out of pocket for AOMs

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The safe zone (36 to 46 degrees F) This is standard refrigerator temperature, 36 to 46 degrees Fahrenheit (2 to 8 degrees Celsius)